rna oligonucleotides (Sangon Biotech)
86
Structured Review
Sangon Biotech
rna oligonucleotides
Rna Oligonucleotides, supplied by Sangon Biotech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rna+oligonucleotides/oligonucleotides/pm42259648-55-3-11
Average 86 stars, based on 1 article reviews
Rna Oligonucleotides, supplied by Sangon Biotech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rna+oligonucleotides/oligonucleotides/pm42259648-55-3-11
Average 86 stars, based on 1 article reviews
rna oligonucleotides - by Bioz Stars,
2026-11
86/100 stars
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Article Snippet: Osteoarthritis (OA) is a leading cause of global disability, characterized by chronic inflammation, progressive cartilage degradation, and subchondral bone remodeling.. While microRNAs (miRNAs) like miR-143-3p show promising anti-inflammatory and chondroprotective potential, their clinical application is hampered by poor stability and inefficient delivery.. To address this, a vertex-integrated tetrahedral DNA nanoframe (Tvi-miR143) is developed for the stable and controlled delivery of miR-143-3p. Article Title: Visualizing single-base RNA mutations in living cells through DNA nanostructure-mediated amplification Article Snippet: .. All DNA and Article Title: Digital Hydrogel Fluorescent-Enhancing Microspheres via CRISPR/Cas12a for Amplification-Free Relative Quantification of Nucleic Acids. Article Snippet: CRISPR/Cas systems hold great promise for molecular diagnostics, but their amplification-free applications are hampered by weak signals and poor quantification.. Here, we developed CrisprDEM, a CRISPR/Cas12a-based digital hydrogel fluorescent-enhancing microsphere system that integrates hydrogel microsphere confinement, microfluidic digital imaging, and machine learning for ultrasensitive and quantitative nucleic acid detection without amplification.. Hydrogel microspheres (HMs) efficiently captured and spatially concentrated CRISPR/Cas12a reaction reporters, achieving a 1000-fold signal amplification compared with homogeneous methods. Article Title: Rational design of CRISPR–Cas12a crRNAs for enhanced allelic discrimination and low-abundance variant detection Article Snippet: Accurate detection of single-nucleotide variants (SNVs) is critical for precision diagnostics but is often limited by sequence context, off-target activation, and amplification-induced noise.. CRISPR–Cas, though highly programmable, is constrained by PAM requirements and sequence-dependent variability.. 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All DNA and Article Title: Rational design of CRISPR–Cas12a crRNAs for enhanced allelic discrimination and low-abundance variant detection Article Snippet: Accurate detection of single-nucleotide variants (SNVs) is critical for precision diagnostics but is often limited by sequence context, off-target activation, and amplification-induced noise.. CRISPR–Cas, though highly programmable, is constrained by PAM requirements and sequence-dependent variability.. Here, we present a programmable framework for ultra-sensitive SNV detection using CRISPR-Cas12a, integrating mutation-guided crRNA design (M-crRNA), split-target crRNAs (S-crRNA), and PfAgo-mediated programmable cleavage. Modification:Article Title: Digital Hydrogel Fluorescent-Enhancing Microspheres via CRISPR/Cas12a for Amplification-Free Relative Quantification of Nucleic Acids. Article Snippet: CRISPR/Cas systems hold great promise for molecular diagnostics, but their amplification-free applications are hampered by weak signals and poor quantification.. Here, we developed CrisprDEM, a CRISPR/Cas12a-based digital hydrogel fluorescent-enhancing microsphere system that integrates hydrogel microsphere confinement, microfluidic digital imaging, and machine learning for ultrasensitive and quantitative nucleic acid detection without amplification.. Hydrogel microspheres (HMs) efficiently captured and spatially concentrated CRISPR/Cas12a reaction reporters, achieving a 1000-fold signal amplification compared with homogeneous methods. Article Title: Rational design of CRISPR–Cas12a crRNAs for enhanced allelic discrimination and low-abundance variant detection Article Snippet: Accurate detection of single-nucleotide variants (SNVs) is critical for precision diagnostics but is often limited by sequence context, off-target activation, and amplification-induced noise.. CRISPR–Cas, though highly programmable, is constrained by PAM requirements and sequence-dependent variability.. Here, we present a programmable framework for ultra-sensitive SNV detection using CRISPR-Cas12a, integrating mutation-guided crRNA design (M-crRNA), split-target crRNAs (S-crRNA), and PfAgo-mediated programmable cleavage. Purification:Article Title: Rational design of CRISPR–Cas12a crRNAs for enhanced allelic discrimination and low-abundance variant detection Article Snippet: Accurate detection of single-nucleotide variants (SNVs) is critical for precision diagnostics but is often limited by sequence context, off-target activation, and amplification-induced noise.. CRISPR–Cas, though highly programmable, is constrained by PAM requirements and sequence-dependent variability.. Here, we present a programmable framework for ultra-sensitive SNV detection using CRISPR-Cas12a, integrating mutation-guided crRNA design (M-crRNA), split-target crRNAs (S-crRNA), and PfAgo-mediated programmable cleavage. |